Neurobiology with caged calcium

被引:115
作者
Ellis-Davies, Graham C. R. [1 ]
机构
[1] Drexel Univ, Dept Physiol & Pharmacol, Coll Med, Philadelphia, PA 19102 USA
关键词
D O I
10.1021/cr078210i
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A review on the wide variety of cells and cellular functions regulated by ionized calcium (Ca2+) is given as well as the history of the development of caged Ca2+ molecules referring to the requirements of the experimental application of each photosensitive probe. The term "caged" is defined to be the functional encapsulation of a chemical messenger in a biologically inert and photosensitive form. Specific topics include: on what does Ca2+ inside cells; the key biological applications of caged Ca2+; and finally, the two-photon uncaging of Ca2+ in living cells.
引用
收藏
页码:1603 / 1613
页数:11
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