Asymmetric addition of trimethylsilyl cyanide to aldehydes catalysed by chiral (salen)Ti-IV complexes

被引：62

作者：

Belokon, Y ^{[1
]}

Flego, M ^{[1
]}

Ikonnikov, N ^{[1
]}

Moscalenko, M ^{[1
]}

North, M ^{[1
]}

Orizu, C ^{[1
]}

Tararov, V ^{[1
]}

Tasinazzo, M ^{[1
]}

机构：

[1] UNIV WALES,DEPT CHEM,BANGOR LL57 2UW,GWYNEDD,WALES

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 09期

关键词：

D O I：

10.1039/a608097i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric addition of trimethylsilyl cyanide to a range of aldehydes is catalysed by the titanium(IV) complexes of chiral salen derivatives 3-6. The enantiomeric excess of the resulting cyanohydrins is predominantly dependent upon the structure of the aldehyde, with electron-rich aromatic aldehydes giving best results, Electron-deficient aromatic aldehydes give cyanohydrins with low enantiomeric excesses, whilst ketones fail to react.

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页码：1293 / 1295

页数：3

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