Roles of Disrupted-In-Schizophrenia 1-Interacting Protein Girdin in Postnatal Development of the Dentate Gyrus

被引：166

作者：

Enomoto, Atsushi ^{[1
,4
,10
]}

Asai, Naoya ^{[1
]}

Namba, Takashi ^{[5
,6
]}

Wang, Yun ^{[1
]}

Kato, Takuya ^{[1
]}

Tanaka, Motoki ^{[7
]}

Tatsumi, Hitoshi ^{[2
]}

Taya, Shinichiro ^{[3
,8
]}

Tsuboi, Daisuke ^{[3
,8
]}

Kuroda, Keisuke ^{[3
,8
]}

Kaneko, Naoko ^{[9
]}

Sawamoto, Kazunobu ^{[9
]}

Miyamoto, Rieko ^{[1
]}

Jijiwa, Mayumi ^{[1
]}

Murakumo, Yoshiki ^{[1
]}

Sokabe, Masahiro ^{[2
,7
]}

Seki, Tatsunori ^{[6
,10
]}

Kaibuchi, Kozo ^{[3
,8
]}

Takahashi, Masahide ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Pathol, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Physiol, Showa Ku, Nagoya, Aichi 4668550, Japan

[3] Nagoya Univ, Grad Sch Med, Dept Cell Pharmacol, Showa Ku, Nagoya, Aichi 4668550, Japan

[4] Nagoya Univ, Inst Adv Res, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[5] Natl Inst Neurosci, Dept Neurochem, Kodaira, Tokyo 1878502, Japan

[6] Juntendo Univ, Sch Med, Dept Anat, Bunkyo Ku, Tokyo 1138421, Japan

[7] Japan Sci & Technol Agcy, Int Cooperat Res Project Solut Oriented Res Sci &, Cell Mechanosensing, Nagoya, Aichi 4668550, Japan

[8] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan

[9] Nagoya City Univ, Grad Sch Med Sci, Inst Mol Med, Dept Dev & Regenerat Biol,Mizuho Ku, Nagoya, Aichi 4678601, Japan

[10] Tohoku Univ, Grad Sch Med, Ctr Translat & Adv Anim Res, Div Dev Neurosci,Aoba Ku, Sendai, Miyagi 9808575, Japan

来源：

NEURON | 2009年 / 63卷 / 06期

关键词：

NEURONAL POLARITY; DISC1; ADULT; DISRUPTED-IN-SCHIZOPHRENIA-1; NEUROGENESIS; MECHANISMS; EXPRESSION; MIGRATION; TRANSPORT; MOTILITY;

D O I：

10.1016/j.neuron.2009.08.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders, regulates neuronal migration and differentiation during mammalian brain development. Although roles for DISC1 in postnatal neurogenesis in the dentate gyrus (DG) have recently emerged, it is not known how DISC1 and its interacting proteins govern the migration, positioning, and differentiation of dentate granule cells (DGCs). Here, we report that DISC1 interacts with the actin-binding protein girdin to regulate axonal development. DGCs in girdin-deficient neonatal mice exhibit deficits in axonal sprouting in the cornu ammonis 3 region of the hippocampus.' Girdin deficiency, RNA interference-mediated knockdown, and inhibition of the DISC1/girdin interaction lead to overextended migration and mispositioning of the DGCs resulting in profound cytoarchitectural disorganization of the DG. These findings identify girdin as an intrinsic factor in postnatal development of the DG and provide insights into the critical role of the DISC1/girdin interaction in postnatal neurogenesis in the DG.

引用

页码：774 / 787

页数：14

共 41 条

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