Livin/melanoma inhibitor of apoptosis protein as a potential therapeutic target for the treatment of malignancy

被引：74

作者：

Chang, Hong

Schimmer, Aaron D.

机构：

[1] Princess Margaret Hosp, Toronto, ON M5G 2M9, Canada

[2] Ontario Canc Inst, Toronto, ON M4X 1K9, Canada

[3] Shandong Univ, Sch Med, Shandong Provincial Hosp, Dept Surg, Shandong, Peoples R China

来源：

MOLECULAR CANCER THERAPEUTICS | 2007年 / 6卷 / 01期

关键词：

X-LINKED INHIBITOR; MELANOMA INHIBITOR; ML-IAP; LIVIN; SURVIVIN; EXPRESSION; CANCER; FAMILY; SMAC; AUTOANTIBODIES;

D O I：

10.1158/1535-7163.MCT-06-0443

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Livin, also called melanoma inhibitor of apoptosis protein (IAP) or kidney IAP, is a member of the IAP family of caspase inhibitors that selectively binds the endogenous IAP antagonist SMAC and caspase-3, caspase-7, and caspase-9. As such, Livin inhibits apoptosis, and its overexpression renders malignant cells resistant to chemotherapy. Therefore, inhibitors of Livin could be useful adjuncts to chemotherapy in the treatment of malignancies. This review will discuss Livin as a potential therapeutic target and strategies for its inhibition, including antisense oligonucleotides, small-molecule inhibitors, and immune-mediated approaches.

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页码：24 / 30

页数：7

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