Determination of dopamine and its relativity of baicalin in rat nuclei after intravenous administration of flavonoids from Scutellariae radix

被引：13

作者：

Chen, Long ^{[1
]}

Zhang, Lujun ^{[1
]}

Wang, Xueli ^{[1
]}

Lin, Han ^{[1
]}

Du, Lijun ^{[1
]}

机构：

[1] Tsing Hua Univ, Dept Biol Sci & Biotechnol, Lab Pharmaceut Sci, Beijing 100084, Peoples R China

来源：

BIOMEDICAL CHROMATOGRAPHY | 2007年 / 21卷 / 01期

关键词：

baicalin; dopamine; cerebral nuclei; neurotransmitter;

D O I：

10.1002/bmc.722

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Baicalin is an active component of Scutellariae radix extracts. It can cross the blood-brain barrier and distribute in cerebral nuclei. However, its mechanism and the effects on the nuclei where it accumulates remain unclear. We used an HPLC-electrochemical detection method to determine the dopamine in cerebral nuclei after intravenous administration of flavonoids from Scutellariae radix and analyzed the relativity between baicalin and DA in cerebral nuclei. We found that the dopamine system is another target system of brain function which baicalin acts on. Copyright (c) 2006 John Wiley & Sons, Ltd.

引用

页码：84 / 88

页数：5

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