Coordinate regulation of transcription and splicing by steroid receptor coregulators

被引：293

作者：

Auboeuf, D

Hönig, A

Berget, SM

O'Malley, BW

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA

来源：

SCIENCE | 2002年 / 298卷 / 5592期

关键词：

D O I：

10.1126/science.1073734

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent observations indicating that promoter identity influences alternative RNA-processing decisions have created interest in the regulatory interactions between RNA polymerase II transcription and precursor messenger RNA (pre-mRNA) processing. We examined the impact of steroid receptor mediated transcription on RNA processing with reporter genes subject to alternative splicing driven by steroid- sensitive promoters. Steroid hormones affected the processing of pre-mRNA synthesized from steroid-sensitive promoters, but not from steroid-unresponsive promoters, in a steroid receptor dependent and receptor-selective manner. Several nuclear receptor coregulators showed differential splicing effects, suggesting that steroid hormone receptors may simultaneously control gene transcription activity and exon content of the product mRNA by recruiting coregulators involved in both processes.

引用

页码：416 / 419

页数：4

共 16 条

[1] Coupling of transcription with alternative splicing:: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer [J].

Cramer, P ;

Cáceres, JF ;

Cazalla, D ;

Kadener, S ;

Muro, AF ;

Baralle, FE ;

Kornblihtt, AR .

MOLECULAR CELL, 1999, 4 (02) :251-258

[2] Functional association between promoter structure and transcript alternative splicing [J].

Cramer, P ;

Pesce, CG ;

Baralle, FE ;

Kornblihtt, AR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (21) :11456-11460

[3]

Hirose Y, 2000, GENE DEV, V14, P1415

[4] Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM) [J].

Iwasaki, T ;

Chin, WW ;

Ko, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (36) :33375-33383

[5] Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors [J].

Jung, DJ ;

Na, SY ;

Na, DS ;

Lee, JW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (02) :1229-1234

[6] Antagonistic effects of T-Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing [J].

Kadener, S ;

Cramer, P ;

Nogués, G ;

Cazalla, D ;

de la Mata, M ;

Fededa, JP ;

Werbajh, SE ;

Srebrow, A ;

Kornblihtt, AR .

EMBO JOURNAL, 2001, 20 (20) :5759-5768

[7] Initial sequencing and analysis of the human genome [J].

Lander, ES ;

Int Human Genome Sequencing Consortium ;

Linton, LM ;

Birren, B ;

Nusbaum, C ;

Zody, MC ;

Baldwin, J ;

Devon, K ;

Dewar, K ;

Doyle, M ;

FitzHugh, W ;

Funke, R ;

Gage, D ;

Harris, K ;

Heaford, A ;

Howland, J ;

Kann, L ;

Lehoczky, J ;

LeVine, R ;

McEwan, P ;

McKernan, K ;

Meldrim, J ;

Mesirov, JP ;

Miranda, C ;

Morris, W ;

Naylor, J ;

Raymond, C ;

Rosetti, M ;

Santos, R ;

Sheridan, A ;

Sougnez, C ;

Stange-Thomann, N ;

Stojanovic, N ;

Subramanian, A ;

Wyman, D ;

Rogers, J ;

Sulston, J ;

Ainscough, R ;

Beck, S ;

Bentley, D ;

Burton, J ;

Clee, C ;

Carter, N ;

Coulson, A ;

Deadman, R ;

Deloukas, P ;

Dunham, A ;

Dunham, I ;

Durbin, R ;

French, L .

NATURE, 2001, 409 (6822) :860-921

[8]

Lou H, 1999, MOL CELL BIOL, V19, P78

[9] Combinatorial control of gene expression by nuclear receptors and coregulators [J].

McKenna, NJ ;

O'Malley, BW .

CELL, 2002, 108 (04) :465-474

[10] Biological role of estrogen and estrogen receptors [J].

Nilsson, S ;

Gustafsson, JÅ .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2002, 37 (01) :1-28

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