Cell biology of the ESCRT machinery

被引：81

作者：

Hanson, Phyllis I. ^{[1
]}

Shim, Soomin ^{[1
]}

Merrill, Samuel A. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 04期

关键词：

MULTIVESICULAR BODY PATHWAY; ENDOSOME-ASSOCIATED COMPLEX; III PROTEIN; STRUCTURAL MODEL; CYTOKINESIS; TRAFFICKING; RECOGNITION; CARGO; ALIX; BIOGENESIS;

D O I：

10.1016/j.ceb.2009.06.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ESCRT (endosomal sorting complex required for transport) machinery comprises a set of protein complexes that regulate sorting and trafficking into multivesicular bodies en route to the lysosome. The physical mechanism responsible for generating lumenal vesicles in this pathway is unknown. Here we review recent studies suggesting that components of the ESCRT-III complex drive lumenal vesicle formation and consider possible mechanisms for this reaction.

引用

页码：568 / 574

页数：7

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