APOE ε4 and bapineuzumab Infusing pharmacogenomics into Alzheimer disease therapeutics

被引:23
作者
Kaufer, Dan [1 ]
Gandy, Sam [2 ,3 ]
机构
[1] Univ N Carolina, Dept Neurol, Chapel Hill, NC 27599 USA
[2] Mt Sinai Sch Med, Dept Neurol & Psychiat, New York, NY USA
[3] James J Peters Vet Affairs Med Ctr, Bronx, NY USA
关键词
APOLIPOPROTEIN E4; IMMUNIZATION; PATHOLOGY;
D O I
10.1212/WNL.0b013e3181c6784a
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
引用
收藏
页码:2052 / 2053
页数:2
相关论文
共 10 条
[1]
Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization [J].
Orgogozo, JM ;
Gilman, S ;
Dartigues, JF ;
Laurent, B ;
Puel, M ;
Kirby, LC ;
Jouanny, P ;
Dubois, B ;
Eisner, L ;
Flitman, S ;
Michel, BF ;
Boada, M ;
Frank, A ;
Hock, C .
NEUROLOGY, 2003, 61 (01) :46-54
[2]
Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Aβ species in amyloid precursor protein transgenic mice [J].
Petrushina, Irina ;
Ghochikyan, Anahit ;
Mktrichyan, Mikayel ;
Mamikonyan, Gregory ;
Movsesyan, Nina ;
Davtyan, Hayk ;
Patel, Archita ;
Head, Elizabeth ;
Cribbs, David H. ;
Agadjanyan, Michael G. .
JOURNAL OF NEUROSCIENCE, 2007, 27 (46) :12721-12731
[3]
Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease [J].
Poirier, J ;
Delisle, MC ;
Quirion, R ;
Aubert, I ;
Farlow, M ;
Lahiri, D ;
Hui, S ;
Bertrand, P ;
Nalbantoglu, J ;
Gilfix, BM ;
Gauthier, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (26) :12260-12264
[4]
Premkumar DRD, 1996, AM J PATHOL, V148, P2083
[5]
Effects of β-hydroxybutyrate on cognition in memory-impaired adults [J].
Reger, MA ;
Henderson, ST ;
Hale, C ;
Cholerton, B ;
Baker, LD ;
Watson, GS ;
Hyde, K ;
Chapman, D ;
Craft, S .
NEUROBIOLOGY OF AGING, 2004, 25 (03) :311-314
[6]
Relkin NR, 2007, ALZHEIMERS DEMENT, V3, pS196, DOI 10.1016/j.jalz.2007.04.021
[7]
Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease [J].
Risner, M. E. ;
Saunders, A. M. ;
Altman, J. F. B. ;
Ormandy, G. C. ;
Craft, S. ;
Foley, I. M. ;
Zvartau-Hind, M. E. ;
Hosford, D. A. ;
Roses, A. D. .
PHARMACOGENOMICS JOURNAL, 2006, 6 (04) :246-254
[8]
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease [J].
Salloway, S. ;
Sperling, R. ;
Gilman, S. ;
Fox, N. C. ;
Blennow, K. ;
Raskind, M. ;
Sabbagh, M. ;
Honig, L. S. ;
Doody, R. ;
van Dyck, C. H. ;
Mulnard, R. ;
Barakos, J. ;
Gregg, K. M. ;
Liu, E. ;
Lieberburg, I. ;
Schenk, D. ;
Black, R. ;
Grundman, M. .
NEUROLOGY, 2009, 73 (24) :2061-2070
[9]
Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse [J].
Schenk, D ;
Barbour, R ;
Dunn, W ;
Gordon, G ;
Grajeda, H ;
Guido, T ;
Hu, K ;
Huang, JP ;
Johnson-Wood, K ;
Khan, K ;
Kholodenko, D ;
Lee, M ;
Liao, ZM ;
Lieberburg, I ;
Motter, R ;
Mutter, L ;
Soriano, F ;
Shopp, G ;
Vasquez, N ;
Vandevert, C ;
Walker, S ;
Wogulis, M ;
Yednock, T ;
Games, D ;
Seubert, P .
NATURE, 1999, 400 (6740) :173-177
[10]
Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure [J].
Zhong, Ning ;
Weisgraber, Karl H. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (10) :6027-6031