Electron Transfer Photoredox Catalysis: Intramolecular Radical Addition to Indoles and Pyrroles

被引：279

作者：

Tucker, Joseph W. ^{[1
]}

Narayanam, Jagan M. R. ^{[1
]}

Krabbe, Scott W. ^{[1
]}

Stephenson, Corey R. J. ^{[1
]}

机构：

[1] Boston Univ, Dept Chem, Boston, MA 02215 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

ORGANIC-SYNTHESIS; ALDEHYDES; PHOTOCHEMISTRY; ORGANOCATALYSIS; PHOTOPHYSICS; CYCLIZATION; ALKYLATION; REDUCTION; COMPLEXES; MECHANISM;

D O I：

10.1021/ol902703k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The utilization of the photoredox catalyst, tris(2,2'-bipyridyl)ruthenium dichloride, and a household light bulb to effect radical cyclizations onto Indoles and pyrroles at room temperature is reported. A reactive free radical Intermediate is generated via the reduction of an activated C-Br bond by the single electron reductant, Ru(I), generated in a visible light induced photocatalytic cycle. This system represents an expansion of the application of photoredox catalysis in conventional free radical processes.

引用

收藏

页码：368 / 371

页数：4

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