Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo

被引：111

作者：

Trapani, JA

Davis, J

Sutton, VR

Smyth, MJ

机构：

[1] Peter MacCallum Canc Inst, Melbourne, Vic 3002, Australia

[2] Austin Res Inst, John Connell Lab, Heidelberg, Vic 3084, Australia

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(00)00094-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent advances in our understanding of cytolytic effector mechanisms include the partial characterization of caspase-independent apoptotic pathways triggered by granzymes, a realization of the vital importance of perforin and granzymes in the defence against certain virus infections in vivo and the first description of hereditary immunodeficiency due to disordered perforin expression in humans.

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收藏

页码：323 / 329

页数：7

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