The insulin signalling system and the IRS proteins

被引：352

作者：

White, MF ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA

来源：

DIABETOLOGIA | 1997年 / 40卷 / Suppl 2期

关键词：

insulin action; insulin signalling; insulin receptor substrate proteins; signal transduction;

D O I：

10.1007/s001250051387

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

During the past few years, the insulin signalling system has emerged as a flexible network of interacting proteins. By utilizing the insulin receptor substrate (IRS)-proteins (IRS-1 and IRS-2), the insulin signal can be amplified or attenuated independently of insulin binding and tyrosine kinase activity, providing an extensible mechanism for signal transmission in multiple cellular backgrounds. By employing IRS-proteins to engage various signalling proteins, the insulin receptor avoids the stoichiometric constraints encountered by receptors which directly recruit SH2-proteins to their autophosphorylation sites. Finally, the shared use of IRS-proteins by multiple receptors is likely to reveal important connections between insulin and other hormones and cytokines which were previously unrecognized, or observed but unexplained.

引用

页码：S2 / S17

页数：16

共 153 条

[1] HUMAN SKELETAL-MUSCLE INSULIN-RECEPTOR SUBSTRATE-1 - CHARACTERIZATION OF THE CDNA, GENE, AND CHROMOSOMAL LOCALIZATION [J].