Human Rad52 protein promotes single-strand DNA annealing followed by branch migration

被引：81

作者：

Reddy, G

Golub, EI

Radding, CM

机构：

[1] YALE UNIV,SCH MED,DEPT GENET,NEW HAVEN,CT 06510

[2] YALE UNIV,SCH MED,DEPT MOL BIOPHYS & BIOCHEM,NEW HAVEN,CT 06510

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1997年 / 377卷 / 01期

关键词：

human Rad52; DNA renaturation; recombination;

D O I：

10.1016/S0027-5107(97)00057-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the yeast, Saccharomyes cerevisiae, the Rad52 gene is important for both mitotic and meiotic recombination. Homologs of the Rad52 gene have been identified in several eukaryotic organisms, ranging from yeast to man. As reported here, human Rad52 protein binds to both single- and double-stranded DNA; and acting on a pair of single-stranded and partially duplex substrates it promotes annealing of complementary strands of DNA, which is followed by branch migration.

引用

页码：53 / 59

页数：7

共 35 条

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