Paraspeckles: nuclear bodies built on long noncoding RNA

被引：377

作者：

Bond, Charles S. ^{[2
]}

Fox, Archa H. ^{[1
]}

机构：

[1] Univ Western Australia, Med Res Ctr, Western Australian Inst Med Res, Crawley, WA 6009, Australia

[2] Univ Western Australia, Med Res Ctr, Sch Biomed Biomol & Chem Sci, Crawley, WA 6009, Australia

来源：

JOURNAL OF CELL BIOLOGY | 2009年 / 186卷 / 05期

关键词：

MESSENGER-RNA; SPLICING FACTOR; PROTEIN P54(NRB); 68-KDA SUBUNIT; DOMAIN; PSF; EXPRESSION; LOCALIZATION; BINDING; CELLS;

D O I：

10.1083/jcb.200906113

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei. These structures play a role in regulating the expression of certain genes in differentiated cells by nuclear retention of RNA. The core paraspeckle proteins (PSF/SFPQ, P54NRB/NONO, and PSPC1 [ paraspeckle protein 1]) are members of the DBHS ( Drosophila melanogaster behavior, human splicing) family. These proteins, together with the long nonprotein-coding RNA NEAT1 (MEN-epsilon/beta), associate to form paraspeckles and maintain their integrity. Given the large numbers of long noncoding transcripts currently being discovered through whole transcriptome analysis, paraspeckles may be a paradigm for a class of sub-nuclear bodies formed around long noncoding RNA.

引用

页码：637 / 644

页数：8

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