Human genetics illuminates the paths to metabolic disease

被引：221

作者：

O'Rahilly, Stephen ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England

来源：

NATURE | 2009年 / 462卷 / 7271期

基金：

英国惠康基金;

关键词：

GENOME-WIDE ASSOCIATION; SEVERE INSULIN-RESISTANCE; II DIABETES-MELLITUS; EARLY-ONSET OBESITY; BODY-MASS INDEX; FTO GENE; SUSCEPTIBILITY LOCI; COMMON VARIANTS; RISK LOCI; ENDOPLASMIC-RETICULUM;

D O I：

10.1038/nature08532

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Metabolic diseases represent a growing threat to world-wide public health. In general, these disorders result from the interaction of heritable factors with environmental influences. Here, I will focus on two important metabolic disorders, namely type 2 diabetes and obesity, and explore the extent to which human molecular genetic research has illuminated our understanding of their underlying pathophysiological mechanisms.

引用

页码：307 / 314

页数：8

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