Inhibitors of sphingolipid metabolism enzymes

被引：159

作者：

Delgado, Antonio

Casas, Josefina

Llebaria, Amadeu

Abad, Jose Luis

Fabrias, Gemma

机构：

[1] CSIC, Chem & Environm Res Inst Barcelona, IIQAB, Dept Biol Organ Chem,Res Unit Bioact Mol, ES-08034 Barcelona, Spain

[2] Univ Barcelona, Fac Pharm, Unit Pharmaceut Chem, CSIC,Associated Unit, E-08028 Barcelona, Spain

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2006年 / 1758卷 / 12期

关键词：

biosynthesis; sphingolipids; metabolism; inhibitor; enzyme;

D O I：

10.1016/j.bbamem.2006.08.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Sphingolipids are a family of lipids that play essential roles both as structural cell membrane components and in cell signalling. The cellular contents of the various sphingolipid species are controlled by enzymes involved in their metabolic pathways. In this context, the discovery of small chemical entities able to modify these enzyme activities in a potent and selective way should offer new pharmacological tools and therapeutic agents. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1957 / 1977

页数：21

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