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Complement in allergy and asthma

被引：73
作者：
Gerard, NP [1 ]
Gerard, C
机构：
[1] Harvard Univ, Childrens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA
[2] Harvard Univ, Childrens Hosp, Sch Med, Dept Pediat, Boston, MA 02115 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 06期
关键词：
D O I：
10.1016/S0952-7915(02)00410-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The complement system is a vital link between innate and adaptive immunity. Recently, several investigators have implicated the complement anaphylatoxins C3a and C5a as potential effectors in Type 1 hypersensitivity reactions, including urticaria, rhinitis and asthma. Thus, complement activation may synergize with classical IgE mediated responses, and inhibition of complement may prove therapeutic.
引用
收藏
页码：705 / 708
页数：4
相关论文
共 30 条
  • [1] Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats
    Abe, M
    Shibata, K
    Akatsu, H
    Shimizu, N
    Sakata, N
    Katsuragi, T
    Okada, H
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (08) : 4651 - 4660
  • [2] Molecular cloning and characterization of the human anaphylatoxin C3a receptor
    Ames, RS
    Li, Y
    Sarau, HM
    Nuthulaganti, P
    Foley, JJ
    Ellis, C
    Zeng, ZZ
    Su, K
    Jurewicz, AJ
    Hertzberg, RP
    Bergsma, DJ
    Kumar, C
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (34) : 20231 - 20234
  • [3] The role of complement in inflammation and adaptive immunity
    Barrington, R
    Zhang, M
    Fischer, M
    Carroll, MC
    [J]. IMMUNOLOGICAL REVIEWS, 2001, 180 : 5 - 15
  • [4] Cutting edge:: Guinea pigs with a natural C3a-receptor defect exhibit decreased bronchoconstriction in allergic airway disease:: Evidence for an involvement of the C3a anaphylatoxin in the pathogenesis of asthma
    Bautsch, W
    Hoymann, HG
    Zhang, QW
    Meier-Wiedenbach, I
    Raschke, U
    Ames, RS
    Sohns, B
    Flemme, N
    zu Vilsendorf, AM
    Grove, M
    Klos, A
    Köhl, J
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (10) : 5401 - 5405
  • [5] EXPRESSION CLONING OF A RECEPTOR FOR C5A ANAPHYLATOXIN ON DIFFERENTIATED HL-60 CELLS
    BOULAY, F
    MERY, L
    TARDIF, M
    BROUCHON, L
    VIGNAIS, P
    [J]. BIOCHEMISTRY, 1991, 30 (12) : 2993 - 2999
  • [6] The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg74
    Cain, SA
    Monk, PN
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (09) : 7165 - 7169
  • [7] Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells
    Crass, T
    Raffetseder, U
    Martin, U
    Grove, M
    Klos, A
    Kohl, J
    Bautsch, W
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (08) : 1944 - 1950
  • [8] Cutting edge: The absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy
    Drouin, SM
    Corry, DB
    Kildsgaard, J
    Wetsel, RA
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (08) : 4141 - 4145
  • [9] Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma
    Drouin, SM
    Kildsgaard, J
    Haviland, J
    Zabner, J
    Jia, HP
    McCray, PB
    Tack, BF
    Wetsel, RA
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 166 (03) : 2025 - 2032
  • [10] Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor
    Farzan, M
    Schnitzler, CE
    Vasilieva, N
    Leung, D
    Kuhn, J
    Gerard, C
    Gerard, NP
    Choe, H
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (09) : 1059 - 1065
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