Adiponectin in health and disease

被引：213

作者：

Oh, Deborah K.

Ciaraldi, Theodore

Henry, Robert R. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[2] VA San Diego Healthcare Syst, San Diego, CA USA

来源：

DIABETES OBESITY & METABOLISM | 2007年 / 9卷 / 03期

关键词：

adiponectin; multimerization; obesity; thiazolidinedione lipodystrophy; type; 2; diabetes;

D O I：

10.1111/j.1463-1326.2006.00610.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adipose tissue is an active metabolic tissue that secretes multiple metabolically important proteins, known as adipokines. Adiponectin is an important adipokine because of its beneficial effects on glucose and lipid metabolism. Low levels of adiponectin are associated with disease states such as diabetes and cardiovascular disease. Direct administration of adiponectin has been shown to be beneficial in animal models of diabetes, obesity and atherosclerosis. Adiponectin levels in humans can be increased through indirect methods such as weight loss or treatment with thiazolidinediones. This article will review the epidemiology and therapeutic options with adiponectin.

引用

页码：282 / 289

页数：8

共 74 条

[1] Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].

Arita, Y ;

Kihara, S ;

Ouchi, N ;

Takahashi, M ;

Maeda, K ;

Miyagawa, J ;

Hotta, K ;

Shimomura, I ;

Nakamura, T ;

Miyaoka, K ;

Kuriyama, H ;

Nishida, M ;

Yamashita, S ;

Okubo, K ;

Matsubara, K ;

Muraguchi, M ;

Ohmoto, Y ;

Funahashi, T ;

Matsuzawa, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83

[2] The adipocyte-secreted protein Acrp30 enhances hepatic insulin action [J].

Berg, AH ;

Combs, TP ;

Du, XL ;

Brownlee, M ;

Scherer, PE .

NATURE MEDICINE, 2001, 7 (08) :947-953

[3] Adiponectin: More than just another fat cell hormone? [J].

Chandran, M ;

Phillips, SA ;

Ciaraldi, T ;

Henry, RR .

DIABETES CARE, 2003, 26 (08) :2442-2450

[4] Lipodystrophy in human immunodeficiency virus-infected patients [J].

Chen, DL ;

Misra, A ;

Garg, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (11) :4845-4856

[5] Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex [J].

Cnop, M ;

Havel, PJ ;

Utzschneider, KM ;

Carr, DB ;

Sinha, MK ;

Boyko, EJ ;

Retzlaff, BM ;

Knopp, RH ;

Brunzell, JD ;

Kahn, SE .

DIABETOLOGIA, 2003, 46 (04) :459-469

[6] A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity [J].

Combs, TP ;

Pajvani, UB ;

Berg, AH ;

Lin, Y ;

Jelicks, LA ;

Laplante, M ;

Nawrocki, AR ;

Rajala, MW ;

Parlow, AF ;

Cheeseboro, L ;

Ding, YY ;

Russell, RG ;

Lindemann, D ;

Hartley, A ;

Baker, GRC ;

Obici, S ;

Deshaies, Y ;

Ludgate, M ;

Rossetti, L ;

Scherer, PE .

ENDOCRINOLOGY, 2004, 145 (01) :367-383

[7]

Combs TP, 2002, ENDOCRINOLOGY, V143, P998, DOI 10.1210/endo.143.3.8662

[8] Plasma adiponectin and pregnancy -: Induced insulin resistance [J].

Cseh, KR ;

Baranyi, E ;

Melczer, Z ;

Kaszás, E ;

Palik, E ;

Winkler, G .

DIABETES CARE, 2004, 27 (01) :274-275

[9] Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese population - The Funagata study [J].

Daimon, M ;

Oizumi, T ;

Saitoh, T ;

Kameda, W ;

Hirata, A ;

Yamaguchi, H ;

Ohnuma, H ;

Igarashi, M ;

Tominaga, M ;

Kato, T .

DIABETES CARE, 2003, 26 (07) :2015-2020

[10] Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women - A randomized trial [J].

Esposito, K ;

Pontillo, A ;

Di Palo, C ;

Giugliano, G ;

Masella, M ;

Marfella, R ;

Giugliano, D .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (14) :1799-1804

← 1 2 3 4 5 6 7 8 →