Solid-phase synthesis of muramyl dipeptide (MDP) derivatives using a multipin method

被引：17

作者：

Liu, G

Zhang, SD

Xia, SQ

Ding, ZK

机构：

[1] Univ Calif Davis, Ctr Canc, Sacramento, CA 95817 USA

[2] Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 12期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0960-894X(00)00241-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Solid-phase synthetic method of muramyl dipeptide derivatives is reported. A diverse library of muramyl dipeptides could be potentially synthesized by acylation, reductive alkylation, sulfonamide formation, urea formation, N-alkylation, amine addition, or component Ugi reactions based on this method for drug screening. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：1361 / 1363

页数：3

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