Antidepressant Medication and Executive Dysfunction: A Deleterious Interaction in Late-Life Depression

被引：59

作者：

Sneed, Joel R. ^{[1
,2
,3
]}

Culang, Michelle E. ^{[2
,3
]}

Keilp, John G. ^{[2
,3
]}

Rutherford, Bret R. ^{[2
,3
]}

Devanand, Davangere P. ^{[2
,3
]}

Roose, Steven P. ^{[2
,3
]}

机构：

[1] CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA

[2] Columbia Univ, New York, NY USA

[3] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

来源：

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 2010年 / 18卷 / 02期

关键词：

Executive dysfunction; response inhibition; treatment outcome; geriatric depression; late-life depression; citalopram; ANTERIOR CINGULATE CORTEX; STROOP TASK-PERFORMANCE; GERIATRIC DEPRESSION; TREATMENT RESPONSE; MISSING-DATA; ATTENTION; OLDER; MRI; INTERFERENCE; ESCITALOPRAM;

D O I：

10.1097/JGP.0b013e3181c796d2

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Objectives: To determine whether there is differential response to placebo or citalopram among older patients with and without deficient response inhibition (DRI). Design: This is an 8-week, double-blind, placebo-controlled trial. Setting: Outpatient psychiatry. Participants: Unipolar depressed patients aged 75 years and older. Intervention: Citalopram (20-40 mg/day) or placebo pill. Measurements: Baseline Stroop Color-Word Test and weekly 24-item Hamilton Rating Scale for Depression assessments. Results: Citalopram-treated patients with DRI did significantly worse than placebo-treated patients with DRI. Conversely, citalopram-treated patients without DRI did significantly better than placebo-treated patients without DRI. Conclusion: Patients with late-life depression and DRI respond worse to selective serotonin reuptake inhibitor (SSRI) than placebo. These findings suggest that there may be a deleterious interaction between DRI and antidepressant medication in late-life depression and that the mechanism of SSRI and placebo response is different. (Am J Geriatr Psychiatry 2010; 18: 128-135)

引用

页码：128 / 135

页数：8

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