Pleiotrophin promotes functional recovery after neural transplantation in rats

被引：42

作者：

Hida, Hideki ^{[1
]}

Masuda, Tadashi ^{[1
]}

Sato, Toyohiro ^{[1
]}

Kim, Tae-Sun ^{[1
]}

Misumi, Sachiyo ^{[1
]}

Nishino, Hitoo ^{[1
]}

机构：

[1] Nagoya City Univ, Dept Neurophysiol & Brain Sci, Grad Sch Med Sci, Mizuho Ku, Nagoya, Aichi 4678601, Japan

来源：

NEUROREPORT | 2007年 / 18卷 / 02期

关键词：

caspase-3; dopamine; glial cell-derived neutropic factor; neural transplantation; rat striatum; survival; trophic factor; 6-hydroxydopamine;

D O I：

10.1097/WNR.0b013e328011398e

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Pleiotrophin promotes survival of dopaminergic neurons in vitro. To investigate whether pleiotrophin promotes survival of grafted dopaminergic neurons in vivo, donor cells from ventral mesencepha-Ion were treated with pleiotrophin (100 ng/ml) during cell preparation and grafted into striatum of hemi-Parkinson model rats. Functional recovery in methamphetamine-induced rotations was improved, and more tyrosine hydroxylase-positive cells survived in the striatum in the pleiotrophin-treated group. Pleiotrophin addition to cells just before transplantation also resulted in better functional recovery; however, no caspase-3 activation was seen during cell preparation. Interestingly, the effect of pleiotrophin on the survival was additive to that of glial-cell line-derived neutropic factor. These results revealed that pleiotrophin had effects on donor cells in neural transplantation in vivo.

引用

页码：179 / 183

页数：5

共 23 条

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