Modelling 'evo-devo' with RNA

被引:128
作者
Fontana, W [1 ]
机构
[1] Santa Fe Inst, Santa Fe, NM 87501 USA
关键词
D O I
10.1002/bies.10190
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The folding of RNA sequences into secondary structures is a simple yet biophysically grounded model of a genotype-phenotype map. Its computational and mathematical analysis has uncovered a surprisingly rich statistical structure characterized by shape space covering, neutral networks and plastogenetic congruence. I review these concepts and discuss their evolutionary implications. (C) 2002 Wiley Periodicals, Inc.
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页码:1164 / 1177
页数:14
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