Nocturnal urinary 6-sulphatoxymelatonin excretion is decreased in primary breast cancer patients compared to age-matched controls and shows negative correlation with tumor-size

被引:41
作者
Bartsch, C
Bartsch, H
Karenovics, A
Franz, H
Peiker, G
Mecke, D
机构
[1] UNIV JENA,DEPT GYNECOL,D-07743 JENA,GERMANY
[2] UNIV TUBINGEN,INST PHYSIOL CHEM,D-72076 TUBINGEN,GERMANY
关键词
urinary 6-sulphatoxymelatonin excretion; breast cancer patients; tumor-size;
D O I
10.1111/j.1600-079X.1997.tb00335.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In previous studies a tumor-size dependent decline of the circadian amplitude of serum melatonin was found in primary unoperated breast cancer patients, which was not due to changes of the hepatic metabolism of melatonin since its main peripheral metabolite, 6-sulphatoxymelatonin (aMT6s), showed similar serum levels. The aim of the current study was to verify these previous results by measurements of the nocturnal excretion of aMT6s in urine. The determination of aMT6s was carried out by radioimmunoassay. 17 primary unoperated breast cancer (BC) patients and 34 age-matched control patients with different types of benign gynecological diseases awaiting operation (breast diseases, n=13; ovarian diseases, n=12; and uterine diseases, n=9) were analysed. The median nocturnal urinary aMT6s excretion (22:00-6:00 hr) was significantly lower (-48%, P=0.033) in BC patients than in controls. Controls showed a significant negative linear regression with age (r=-0.419, P=0.014). According to multivariate linear regression analysis, BC revealed no age-dependency but a significant negative effect of increasing tumor-size on aMT6s-excretion (P=0.036) was detected. These results confirm previous findings of a decreased pineal melatonin secretion in BC patients as well as an inverse relationship with tumor-size excluding a possible distortion due to age. The mechanisms involved are unknown but indicate that BC may lead to an impaired production of pineal melatonin. The clinical relevance of these findings from therapeutic and diagnostic point of view is discussed.
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页码:53 / 58
页数:6
相关论文
共 32 条
[1]  
ALDOUS ME, 1988, ANN CLIN BIOCHEM, V25, P298
[2]  
[Anonymous], 1992, TNM classification of malignant tumors
[3]  
BARTSCH C, 1991, CANCER, V67, P1681, DOI 10.1002/1097-0142(19910315)67:6<1681::AID-CNCR2820670634>3.0.CO
[4]  
2-0
[5]   MELATONIN AND 6-SULFATOXYMELATONIN CIRCADIAN-RHYTHMS IN SERUM AND URINE OF PRIMARY PROSTATE-CANCER PATIENTS - EVIDENCE FOR REDUCED PINEAL ACTIVITY AND RELEVANCE OF URINARY DETERMINATIONS [J].
BARTSCH, C ;
BARTSCH, H ;
SCHMIDT, A ;
ILG, S ;
BICHLER, KH ;
FLUCHTER, SH .
CLINICA CHIMICA ACTA, 1992, 209 (03) :153-167
[6]   URINARY MELATONIN LEVELS IN HUMAN-BREAST CANCER-PATIENTS [J].
BARTSCH, C ;
BARTSCH, H ;
JAIN, AK ;
LAUMAS, KR ;
WETTERBERG, L .
JOURNAL OF NEURAL TRANSMISSION, 1981, 52 (04) :281-294
[7]  
BARTSCH C, 1995, ONCOLOGY-BASEL, V52, P278
[8]   DIMINISHED PINEAL FUNCTION COINCIDES WITH DISTURBED CIRCADIAN ENDOCRINE RHYTHMICITY IN UNTREATED PRIMARY-CANCER PATIENTS - CONSEQUENCE OF PREMATURE AGING OR OF TUMOR-GROWTH [J].
BARTSCH, C ;
BARTSCH, H ;
FLUCHTER, SH ;
MECKE, D ;
LIPPERT, TH .
AGING CLOCK: THE PINEAL GLAND AND OTHER PACEMAKERS IN THE PROGRESSION OF AGING AND CARCINOGENESIS, 1994, 719 :502-525
[9]  
BARTSCH C, 1994, ADV PINEAL, V8, P479
[10]  
BARTSCH C, 1992, CANCER J - FRANCE, V5, P194