Regulator of G-protein signaling (RGS) proteins in cancer biology

被引：133

作者：

Hurst, Jillian H. ^{[1
]}

Hooks, Shelley B. ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2009年 / 78卷 / 10期

关键词：

Regulator of G-protein signaling proteins; Cancer; G-protein coupled receptors; Signal transduction; GROWTH-FACTOR RECEPTOR; GENE-EXPRESSION PROFILES; MUTANT ALPHA-SUBUNIT; CELL LUNG-CANCER; BETA-CATENIN; PROSTATE-CANCER; LYSOPHOSPHATIDIC ACID; MESSENGER-RNA; COUPLED RECEPTORS; MUTATIONAL ANALYSES;

D O I：

10.1016/j.bcp.2009.06.028

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The regulator of G-protein signaling (RGS) family is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). In recent years, GPCRs have been linked to the initiation and progression of multiple cancers; thus, regulators of GPCR signaling are also likely to be important to the pathophysiology of cancer. This review highlights recent studies detailing changes in RGS transcript expression during oncogenesis, single nucleotide polymorphisms in RGS proteins linked to lung and bladder cancers, and specific roles for RGS proteins in multiple cancer types. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1289 / 1297

页数：9

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