Regulator of G-protein signaling (RGS) proteins in cancer biology

被引：133

作者：

Hurst, Jillian H. ^{[1
]}

Hooks, Shelley B. ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2009年 / 78卷 / 10期

关键词：

Regulator of G-protein signaling proteins; Cancer; G-protein coupled receptors; Signal transduction; GROWTH-FACTOR RECEPTOR; GENE-EXPRESSION PROFILES; MUTANT ALPHA-SUBUNIT; CELL LUNG-CANCER; BETA-CATENIN; PROSTATE-CANCER; LYSOPHOSPHATIDIC ACID; MESSENGER-RNA; COUPLED RECEPTORS; MUTATIONAL ANALYSES;

D O I：

10.1016/j.bcp.2009.06.028

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The regulator of G-protein signaling (RGS) family is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). In recent years, GPCRs have been linked to the initiation and progression of multiple cancers; thus, regulators of GPCR signaling are also likely to be important to the pathophysiology of cancer. This review highlights recent studies detailing changes in RGS transcript expression during oncogenesis, single nucleotide polymorphisms in RGS proteins linked to lung and bladder cancers, and specific roles for RGS proteins in multiple cancer types. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1289 / 1297

页数：9

共 125 条

[31]

Fischer OM, 2003, BIOCHEM SOC T, V31, P1203

[32] RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho? [J].

Fukuhara, S ;

Chikumi, H ;

Gutkind, JS .

ONCOGENE, 2001, 20 (13) :1661-1668

[33] Expression of regulator of G protein signalling protein 5 (RGS5) in the tumour vasculature of human renal cell carcinoma [J].

Furuya, M ;

Nishiyama, M ;

Kimura, S ;

Suyama, T ;

Naya, Y ;

Ito, H ;

Nikaido, T ;

Ishikura, H .

JOURNAL OF PATHOLOGY, 2004, 203 (01) :551-558

[34] The roles of FLT3 in hematopoiesis and leukemia [J].

Gilliland, DG ;

Griffin, JD .

BLOOD, 2002, 100 (05) :1532-1542

[35] Generation and characterization of Rgs4 mutant mice [J].

Grillet, N ;

Pattyn, A ;

Contet, C ;

Kieffer, BL ;

Goridis, C ;

Brunet, JF .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (10) :4221-4228

[36] Generation of antigen-specific CTL responses using RGS1 mRNA transfected dendritic cells [J].

Gruenebach, Frank ;

Erndt, Stefanie ;

Haentschel, Maik ;

Heine, Annkristin ;

Brossart, Peter .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2008, 57 (10) :1483-1491

[37] A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans [J].

Gu, Jian ;

Wu, Xifeng ;

Dong, Qiong ;

Romeo, Martin J. ;

Lin, Xin ;

Gutkind, J. Silvio ;

Berman, David M. .

CANCER, 2006, 106 (12) :2716-2724

[38] Cell growth control by G protein-coupled receptors: from signal transduction to signal integration [J].

Gutkind, JS .

ONCOGENE, 1998, 17 (11) :1331-1342

[39] Vascular normalization in Rgs5-deficient tumours promotes immune destruction [J].

Hamzah, Juliana ;

Jugold, Manfred ;

Kiessling, Fabian ;

Rigby, Paul ;

Manzur, Mitali ;

Marti, Hugo H. ;

Rabie, Tamer ;

Kaden, Sylvia ;

Groene, Hermann-Josef ;

Haemmerling, Guenter J. ;

Arnold, Bernd ;

Ganss, Ruth .

NATURE, 2008, 453 (7193) :410-U67

[40] RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization [J].

Han, Jang-Il ;

Huang, Ning-Na ;

Kim, Dong-Uk ;

Kehrl, John H. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2006, 79 (06) :1357-1368

← 1 2 3 4 5 6 7 8 9 10 →