Effect of penetration enhancers on isosorbide dinitrate penetration through rat skin from a transdermal therapeutic system

被引：25

作者：

Gabiga, H ^{[1
]}

Cal, K ^{[1
]}

Janicki, S ^{[1
]}

机构：

[1] Med Univ Gdansk, Dept Pharmaceut Technol, PL-80416 Gdansk, Poland

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2000年 / 199卷 / 01期

关键词：

isosorbide dinitrate; isosorbide mononitrate; percutaneous absorption; skin penetration enhancers;

D O I：

10.1016/S0378-5173(99)00363-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Percutaneous absorption of isosorbide dinitrate (ISDN) from a transdermal therapeutic system (TTS) with or without penetration enhancers was studied. The concentration of ISDN and its metabolites, isosorbide-5-mononitrate (IS-5-MN) and isosorbide-2-mononitrate (IS-2-MN), was determined in rat plasma during a 48 h application of TTS. The increased skin-penetration enhancing: effect of oleic acid and propylene glycol in comparison to polyethylene glycol 400 and isopropyl myristate on percutaneous permeation of ISDN was shown. It was expressed by higher values of C-max and AUC. After the application of TTS, a lower ISDN and molar ratio of its metabolites was observed than after oral;administration. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 6

页数：6

共 13 条

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