Adult brain neurogenesis and depression

被引：120

作者：

Jacobs, BL ^{[1
]}

机构：

[1] Princeton Univ, Program Neurosci, Princeton, NJ 08544 USA

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2002年 / 16卷 / 05期

关键词：

neurogenesis; depression; brain; cytokines; interleukin; serotonin; 5-HT1A receptor; stress; dentate gyrus; hippocampus;

D O I：

10.1016/S0889-1591(02)00015-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The waning and waxing of neurogenesis in brain areas such as the dentate gyrus is proposed as a key factor in the descent into and recovery from clinical depression, respectively. A decrease in neurogenesis could occur due to genetic factors, stress (especially because of the involvement of adrenal corticoids), and/or a decline in serotonergic neurotransmission. An increase in neurogenesis could be brought about by several factors, but especially those that activate the serotonin 5-HT1A receptor. The possible interaction of immune system factors, especially the proinflammatory cytokines, with adult brain neurogenesis is discussed. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：602 / 609

页数：8

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