Caloric restriction, SIRT1 and longevity

被引：349

作者：

Canto, Caries ^{[1
]}

Auwerx, Johan ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, CH-1015 Lausanne, Switzerland

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2009年 / 20卷 / 07期

基金：

欧洲研究理事会;

关键词：

ACTIVATED PROTEIN-KINASE; LIFE-SPAN EXTENSION; NEMATODE CAENORHABDITIS-ELEGANS; SMALL-MOLECULE ACTIVATORS; SACCHAROMYCES-CEREVISIAE; RHESUS-MONKEYS; DIETARY RESTRICTION; C-ELEGANS; MITOCHONDRIAL-FUNCTION; NICOTINAMIDE RIBOSIDE;

D O I：

10.1016/j.tem.2009.03.008

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

More than 70 years after its initial report, caloric restriction stands strong as the most consistent non-pharmacological intervention increasing lifespan and protecting against metabolic disease. Among the different mechanisms by which caloric restriction might act, Sir2/SIRT1 (Silent information regulator 2/Silent information regulator T1) has been the focus of much attention because of its ability to integrate sensing of the metabolic status with adaptive transcriptional outputs. This review focuses on gathered evidence suggesting that Sir2/SIRT1 is a key mediator of the beneficial effects of caloric restriction and addresses the main questions that still need to be answered to consolidate this hypothesis.

引用

页码：325 / 331

页数：7

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