Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance

被引：368

作者：

Petersen, Max C. ^{[1
]}

Shulman, Gerald I. ^{[1
,2
,3
]}

机构：

[1] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06520 USA

[3] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2017年 / 38卷 / 07期

基金：

美国国家卫生研究院;

关键词：

FATTY LIVER-DISEASE; PROTEIN-KINASE-C; COA DEHYDROGENASE-DEFICIENCY; TYPE-2; DIABETES-MELLITUS; DIET-INDUCED OBESITY; FED MICE; GLUCOSE-HOMEOSTASIS; KNOCKOUT MICE; ENERGY-EXPENDITURE; CELLULAR MECHANISM;

D O I：

10.1016/j.tips.2017.04.004

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Although ample evidence links hepatic lipid accumulation with hepatic insulin resistance, the mechanistic basis of this association is incompletely understood and controversial. Diacylglycerols (DAGs) and ceramides have emerged as the two best-studied putative mediators of lipid-induced hepatic insulin resistance. Both lipids were first associated with insulin resistance in skeletal muscle and were subsequently hypothesized to mediate insulin resistance in the liver. However, the putative roles for DAGs and ceramides in hepatic insulin resistance have proved more complex than originally imagined, with various genetic and pharmacologic manipulations yielding a vast and occasionally contradictory trove of data to sort. In this review we examine the state of this field, turning a critical eye toward both DAGs and ceramides as putative mediators of lipid-induced hepatic insulin resistance.

引用

页码：649 / 665

页数：17

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