Swine influenza matrix 2 (M2) protein contributes to protection against infection with different H1 swine influenza virus (SIV) isolates

被引：35

作者：

Kitikoon, Pravina ^{[1
]}

Vincent, Amy L. ^{[2
]}

Janke, Bruce H. ^{[1
]}

Erickson, B. ^{[1
]}

Strait, Erin L. ^{[1
]}

Yu, Shan ^{[1
]}

Gramer, Marie R. ^{[3
]}

Thacker, Eileen L. ^{[1
]}

机构：

[1] Iowa State Univ, Coll Vet Med, Ames, IA 50011 USA

[2] ARS, Virus & Prion Dis Livestock Res Unit, Natl Anim Dis Ctr, USDA, Ames, IA USA

[3] Univ Minnesota, Minnesota Vet Diagnost Lab, St Paul, MN 55108 USA

来源：

VACCINE | 2009年 / 28卷 / 02期

关键词：

Swine influenza virus; Vaccine; M2; vaccine; A VIRUS; EXTRACELLULAR DOMAIN; ANTIBODY-RESPONSES; IMMUNE-RESPONSES; CROSS-PROTECTION; UNITED-STATES; VACCINE; PIGS; HEMAGGLUTININ; MICE;

D O I：

10.1016/j.vaccine.2009.09.130

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A swine influenza virus (SIV) vaccine-challenge pig model was used to study the potential of a conserved matrix 2 (M2) protein vaccine alone or in combination with an inactivated H1N1-vaccine to protect against H1N1 and H1N2 viruses. The H1N1-vaccine and heterologous H1N2-challenge virus model has previously been shown to prolong fever and increase SIV-associated pneumonic lesions. The M2 vaccine in combination with the H1N1-vaccine reduced the H1N2 induced fever but not virus shedding. The M2 vaccine alone reduced respiratory signs and pneumonic lesions to levels similar to the negative control pigs following H1N2 infection. This study found that the M2 protein has potential as a vaccine for SIV-associated disease prevention. However, development of an immune response towards the major envelope HA protein was required to reduce SIV shedding. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：523 / 531

页数：9

共 45 条

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