Sex differences in cortical neuroplasticity in humans

被引：99

作者：

Kuo, Min-Fang ^{[1
]}

Paulus, Walter ^{[1
]}

Nitsche, Michael A. ^{[1
]}

机构：

[1] Univ Gottingen, Dept Clin Neurophysiol, D-37075 Gottingen, Germany

来源：

NEUROREPORT | 2006年 / 17卷 / 16期

关键词：

brain stimulation; gender; human; neuroplasticity;

D O I：

10.1097/01.wnr.0000239955.68319.c2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present study, we explore sex differences of neuroplasticity in humans, as revealed by transcranial direct current stimulation, which induces motor cortical excitability changes both during and after stimulation. We retrospectively re-analyzed data collected from previous transcranial direct current stimulation studies. In women, the excitability-diminishing after-effects of cathodal transcranial direct current stimulation were relevantly prolonged compared with the male group. Similarly, during a short direct current stimulation that elicits no after-effects, the female group showed more inhibition. In contrast, no significant differences between male and female study participants were found for excitability-enhancing anodal transcranial direct current stimulation. These results suggest sex differences, possibly due to the effects of sex hormones, in the modulation of human cortical plasticity.

引用

页码：1703 / 1707

页数：5

共 25 条

[1]

[Anonymous], ANN REV SEX RES

[2] Why sex matters for neuroscience [J].

Cahill, Larry .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (06) :477-484

[3] 17β-estradiol:: Effect on CA1 hippocampal synaptic plasticity [J].

Foy, MR .

NEUROBIOLOGY OF LEARNING AND MEMORY, 2001, 76 (03) :239-252

[4] Transcallosal inhibition across the menstrual cycle:: A TMS study [J].

Hausmann, M ;

Tegenthoff, M ;

Sänger, J ;

Janssen, F ;

Güntürkün, O ;

Schwenkreis, P .

CLINICAL NEUROPHYSIOLOGY, 2006, 117 (01) :26-32

[5] Transcranial Magnetic Stimulation Evidence of a Potential Role for Progesterone in the Modulation of Premenstrual Corticocortical Inhibition in a Woman with Catamenial Seizure Exacerbation [J].

Herzog, Andrew G. ;

Friedman, Mark N. ;

Freund, Stefanie ;

Pascual-Leone, Alvaro .

EPILEPSY & BEHAVIOR, 2001, 2 (04) :367-369

[6] Ovarian hormones and cortical excitability.: An rTMS study in humans [J].

Inghilleri, M ;

Conte, A ;

Currà, A ;

Frasca, V ;

Lorenzano, C ;

Berardelli, A .

CLINICAL NEUROPHYSIOLOGY, 2004, 115 (05) :1063-1068

[7] Meta-analysis of sex differences in rodent models of learning and memory: a review of behavioral and biological data [J].

Jonasson, Z .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2005, 28 (08) :811-825

[8]

Kimura Doreen, 2002, Neuro Endocrinol Lett, V23 Suppl 4, P67

[9] Role of estrogen in balancing contributions from multiple memory systems [J].

Korol, DL .

NEUROBIOLOGY OF LEARNING AND MEMORY, 2004, 82 (03) :309-323

[10] Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability [J].

Liebetanz, D ;

Nitsche, MA ;

Tergau, F ;

Paulus, W .

BRAIN, 2002, 125 :2238-2247

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