Melanocyte biology and skin pigmentation

被引：962

作者：

Lin, Jennifer Y.

Fisher, David E.

机构：

[1] Childrens Hosp Boston, Dana Farber Canc Inst, Melanoma Program, Boston, MA 02115 USA

[2] Massachusetts Gen Hosp, Harvard Combined Program Dermatol, Boston, MA 02115 USA

[3] Childrens Hosp Boston, Dana Farber Canc Inst, Dept Pediat Hematol & Oncol, Boston, MA 02115 USA

来源：

NATURE | 2007年 / 445卷 / 7130期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature05660

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Melanocytes are phenotypically prominent but histologically inconspicuous skin cells. They are responsible for the pigmentation of skin and hair, and thereby contribute to the appearance of skin and provide protection from damage by ultraviolet radiation. Pigmentation mutants in various species are highly informative about basic genetic and developmental pathways, and provide important clues to the processes of photoprotection, cancer predisposition and even human evolution. Skin is the most common site of cancer in humans. Continued understanding of melanocyte contributions to skin biology will hopefully provide new opportunities for the prevention and treatment of skin diseases.

引用

页码：843 / 850

页数：8

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