Systematic review of multiple studies of prognosis: The feasibility of obtaining individual patient data

被引：16

作者：

Altman, Douglas G. ^{[1
]}

Trivella, Marialena ^{[1
]}

Pezzella, Francesco ^{[2
]}

Harris, Adrian L. ^{[3
]}

Pastorino, Ugo ^{[4
]}

机构：

[1] Canc Res UK, NHS Ctr Stat Med, Oxford, England

[2] John Radcliffe Hosp, Cancer Res UK Pathol Unit, Oxford, England

[3] Churchill Hosp, Cancer Res UK Oncol Unit, Oxford OX3 7LJ, England

[4] Ist Nazl Tumori, Milan, Italy

来源：

ADVANCES IN STATISTICAL METHODS FOR THE HEALTH SCIENCES: APPLICATIONS TO CANCER AND AIDS STUDIES, GENOME SEQUENCE ANALYSIS, AND SURVIVAL ANALYSIS | 2007年

关键词：

prognostic markers; systematic review; metaanalysis; individual patient data;

D O I：

10.1007/978-0-8176-4542-7_1

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Studies of prognosis have received rather little attention by those carrying out systematic reviews. Such reviews are increasingly being attempted but the poor quality of published 'primary' studies leads to serious difficulties. Thus there have been calls for such reviews to be based on individual patient data (IPD) but such studies are as yet rare. We consider the advantages of IPD for reviews of prognostic variables and describe in detail a systematic review of microvessel density counts as a prognostic variable for patients with non-small cell lung cancer. We show that such a study is feasible, but note that it may not be cost-effective to attempt to obtain all relevant data.

引用

页码：3 / +

页数：4

共 31 条

[1] DANGERS OF USING OPTIMAL CUTPOINTS IN THE EVALUATION OF PROGNOSTIC FACTORS [J].