Protective effects of huperzine A on β-amyloid25-35 induced oxidative injury in rat pheochromocytoma cells

被引：78

作者：

Xiao, XQ

Wang, R

Han, YF

Tang, XC

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China

[2] Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2000年 / 286卷 / 03期

关键词：

huperzine A; amyloid beta-peptide; free radicals; glutathione peroxidase; catalase; superoxide dismutase; malondialdehyde; PC12; cells;

D O I：

10.1016/S0304-3940(00)01088-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of huperzine A (HupA), a novel acetylcholinesterase inhibitor, on A beta(25-35)-induced cell lesion, level of lipid peroxidation, antioxidant enzyme activities were investigated in the rat pheochromocytoma line PC12. Following a 48 h exposure of the cells to A beta(25-35), a significant reduction in cell survival and activities of glutathione peroxidase (GSH-Px) and catalase (CAT), as well as increased production of malondialdehyde (MDA) and superoxide dismutase (SOD) were observed. Preincubation of the cells with HupA prior to A beta(25-35) exposure elevated the cell survival and GSH-Px and CAT activities, and decreased the level of MDA and SOD activity. The results indicate that HupA has protective effects against A beta-induced cell toxicity, which might be beneficial for the treatment of Alzheimer's disease. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：155 / 158

页数：4

共 21 条

[1]

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