Accelerating water exchange for GdIII chelates by steric compression around the water binding site

被引：79

作者：

Ruloff, R

Tóth, É

Scopelliti, R

Tripier, R

Handel, H

Merbach, AE ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, ICMB, BCH, Lausanne, Switzerland

[2] Univ Bretagne Occidentale, F-29285 Brest, France

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 22期

关键词：

D O I：

10.1039/b207713b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The water exchange process was accelerated for nine-coordinate, monohydrated macrocyclic Gd-III complexes by inducing steric compression around the water binding site; the increased steric crowding was achieved by replacing an ethylene bridge of DOTA(4-) by a propylene bridge;double dagger in addition to the optimal water exchange rate, the stability of [Gd(TRITA)(H2O)](-) is sufficiently high to ensure safe medical use which makes it a potential synthon for the development of high relaxivity, macromolecular MRI contrast agents.

引用

页码：2630 / 2631

页数：2

共 8 条

[1]

Bernard P, 1998, STUD MEDIEV, V39, P1

[2] STABILITIES OF TRIVALENT METAL-ION COMPLEXES OF THE TETRAACETATE DERIVATIVES OF 12-MEMBERED, 13-MEMBERED AND 14-MEMBERED TETRAAZAMACROCYCLES [J].