The role of Sfrp and DKK proteins in cardiomyocyte development

被引：29

作者：

Hsueh, Ying-Chang ^{[1
,2
]}

Hodgkinson, Conrad P. ^{[1
,2
]}

Gomez, Jose A. ^{[3
]}

机构：

[1] Duke Univ, Mandel Ctr Heart & Vasc Res, Med Ctr, Durham, NC USA

[2] Duke Univ, Duke Cardiovasc Res Ctr, Med Ctr, Durham, NC USA

[3] Vanderbilt Univ, Med Ctr, Dept Med, Clin Pharmacol Div, 2220 Pierce Ave,502 RRB, Nashville, TN 37232 USA

来源：

PHYSIOLOGICAL REPORTS | 2021年 / 9卷 / 03期

关键词：

cardiomyocyte; DKK; Sfrp2; FRIZZLED-RELATED PROTEIN-2; WNT SIGNALING PATHWAY; PLANAR CELL POLARITY; 2ND HEART FIELD; WNT/BETA-CATENIN; BETA-CATENIN; PRESSURE-OVERLOAD; CARDIAC PROGENITORS; DIFFERENTIATION; APOPTOSIS;

D O I：

10.14814/phy2.14678

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical beta-catenin signaling pathways and Wnt noncanonical signaling pathways involving PCP and JNK. We also describe recent literature which suggests that endogenous Wnt inhibitors such as the Sfrp and DKK proteins play important roles in regulating the cardiomyocyte differentiation.

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页数：9

相关论文

共 92 条

[1]

Wnt5a is elevated in heart failure and affects cardiac fibroblast function [J].

Abraityte, Aurelija ;

Vinge, Leif E. ;

Askevold, Erik T. ;

Lekva, Tove ;

Michelsen, Annika E. ;

Ranheim, Trine ;

Alfsnes, Katrine ;

Fiane, Arnt ;

Aakhus, Svend ;

Lunde, Ida G. ;

Dahl, Christen P. ;

Aukrust, Pal ;

Christensen, Geir ;

Gullestad, Lars ;

Yndestad, Arne ;

Ueland, Thor .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2017, 95 (07) :767-777

[2]

Interrelationship of canonical and non-canonical Wnt signalling pathways in chronic metabolic diseases [J].

Ackers, Ian ;

Malgor, Ramiro .

DIABETES & VASCULAR DISEASE RESEARCH, 2018, 15 (01) :3-13

[3]

The frizzled/stan Pathway and Planar Cell Polarity in the Drosophila Wing [J].

Adler, Paul N. .

PLANAR CELL POLARITY DURING DEVELOPMENT, 2012, 101 :1-31

[4]

Canonical Wnt signaling functions in second heart field to promote right ventricular growth [J].

Ai, Di ;

Fu, Xueyao ;

Wang, Jun ;

Lu, Mei-Fang ;

Chen, Li ;

Baldini, Antonio ;

Klein, William H. ;

Martin, James F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (22) :9319-9324

[5]

Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue [J].

Ardehali, Reza ;

Ali, Shah R. ;

Inlay, Matthew A. ;

Abilez, Oscar J. ;

Chen, Michael Q. ;

Blauwkamp, Timothy A. ;

Yazawa, Masayuki ;

Gong, Yongquan ;

Nusse, Roeland ;

Drukker, Micha ;

Weissman, Irving L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (09) :3405-3410

[6]

Involvement of FrzA/sFRP-1 and the Wnt/frizzled pathway in ischemic preconditioning [J].

Barandon, L ;

Dufourcq, P ;

Costet, P ;

Moreau, C ;

Allières, C ;

Daret, D ;

Dos Santos, P ;

Lamazière, JMD ;

Couffinhal, T ;

Duplàa, C .

CIRCULATION RESEARCH, 2005, 96 (12) :1299-1306

[7]

Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA [J].

Barandon, L ;

Couffinhal, T ;

Ezan, J ;

Dufourcq, P ;

Costet, P ;

Alzieu, P ;

Leroux, L ;

Moreau, C ;

Dare, D ;

Duplàa, C .

CIRCULATION, 2003, 108 (18) :2282-2289

[8]

Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT [J].

Bisson, Joseph A. ;

Mills, Bradley ;

Helt, Jay-Christian Paul ;

Zwaka, Thomas P. ;

Cohen, Ethan David .

DEVELOPMENTAL BIOLOGY, 2015, 398 (01) :80-96

[9]

Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease [J].

Bovolenta, Paola ;

Esteve, Pilar ;

Ruiz, Jose Maria ;

Cisneros, Elsa ;

Lopez-Rios, Javier .

JOURNAL OF CELL SCIENCE, 2008, 121 (06) :737-746

[10]

Brault V, 2001, DEVELOPMENT, V128, P1253

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