Preparation of new pyridoacridine derivatives and formal synthesis of 11-hydroxyascididemine

被引：11

作者：

Alvarez, M

Feliu, L

Ajana, W

Joule, JA

机构：

[1] Univ Barcelona, Fac Farm, Lab Quim Organ, E-08028 Barcelona, Spain

[2] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

TETRAHEDRON | 2000年 / 56卷 / 23期

关键词：

marine alkaloids; pyridoacridines; cytotoxic compounds;

D O I：

10.1016/S0040-4020(00)00251-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of pyrido[2,3,4-kl]acridin-6-ones substituted at position 4 following our previous methodology is described. A new synthetic route for the preparation of aminopyridoacridone 16, used before for the synthesis of the 11-hydroxyascididemine, is described. The cytotoxic activity of pyridoacridones 19 and 20 in four cell lines is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3703 / 3708

页数：6

共 18 条

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