Polyglutamine expansions: Proteolysis, chaperones, and the dangers of promiscuity

被引：53

作者：

Ferrigno, P

Silver, PA ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Canc Biol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

NEURON | 2000年 / 26卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(00)81132-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

[No abstract available]

引用

页码：9 / 12

页数：4

共 19 条

[1] A HOMOLOG OF THE BACTERIAL HEAT-SHOCK GENE DNAJ THAT ALTERS PROTEIN SORTING IN YEAST
BLUMBERG, H
SILVER, PA
[J]. NATURE, 1991, 349 (6310) : 627 - 630
[2] Chai YH, 1999, J NEUROSCI, V19, P10338
[3] Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice
Cummings, CJ
Reinstein, E
Sun, YL
Antalffy, B
Jiang, YH
Ciechanover, A
Orr, HT
Beaudet, AL
Zoghbi, HY
[J]. NEURON, 1999, 24 (04) : 879 - 892
[4] Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
Davies, SW
Turmaine, M
Cozens, BA
DiFiglia, M
Sharp, AH
Ross, CA
Scherzinger, E
Wanker, EE
Mangiarini, L
Bates, GP
[J]. CELL, 1997, 90 (03) : 537 - 548
[5] Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptor
Diamond, MI
Robinson, MR
Yamamoto, KR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (02) : 657 - 661
[6] CHARACTERIZATION AND LOCALIZATION OF THE HUNTINGTON DISEASE GENE-PRODUCT
HOOGEVEEN, AT
WILLEMSEN, R
MEYER, N
DEROOIJ, KE
ROOS, RAC
VANOMMEN, GJB
GALJAARD, H
[J]. HUMAN MOLECULAR GENETICS, 1993, 2 (12) : 2069 - 2073
[7] Genetic suppression of polyglutamine toxicity in Drosophila
Kazemi-Esfarjani, P
Benzer, S
[J]. SCIENCE, 2000, 287 (5459) : 1837 - 1840
[8] Ataxin-1 nuclear localization and aggregation:: Role in polyglutamine-induced disease in SCA1 transgenic mice
Klement, IA
Skinner, PJ
Kaytor, MD
Yi, H
Hersch, SM
Clark, HB
Zoghbi, HY
Orr, HT
[J]. CELL, 1998, 95 (01) : 41 - 53
[9] Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins
Krobitsch, S
Lindquist, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) : 1589 - 1594
[10] Li SH, 1999, J NEUROSCI, V19, P5159

← 1 2 →