Fleshing out filaggrin phenotypes

被引：107

作者：

Irvine, Alan D. ^{[1
]}

机构：

[1] Our Ladys Hosp Sick Children, Dept Pediat Dermatol, Dublin 12, Ireland

[2] Trinity Coll Dublin, Dept Clin Med, Dublin, Ireland

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2007年 / 127卷 / 03期

关键词：

D O I：

10.1038/sj.jid.5700695

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The association of filaggrin null alleles with eczema has been replicated in several European populations. Three large, well-conducted studies confirm this association and offer insights into the phenotypic nature of eczema associated with these alleles. Early data suggest that FLG-associated eczema may be more persistent, more likely to have palmar hyperlinearity, and more likely to be associated with asthma. These initial hints will require further confirmation in cohort studies.

引用

页码：504 / 507

页数：4

共 14 条

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