A subgenomic mRNA transcript of the coronavirus mouse hepatitis virus strain A59 defective interfering (DI) RNA is packaged when it contains the DI packaging signal

被引：19

作者：

Bos, ECW ^{[1
]}

Dobbe, JC ^{[1
]}

Luytjes, W ^{[1
]}

Spaan, WJM ^{[1
]}

机构：

[1] LEIDEN UNIV,DEPT VIROL,NL-2300 RC LEIDEN,NETHERLANDS

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 07期

关键词：

D O I：

10.1128/JVI.71.7.5684-5687.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In infected cells, only the genomic RNA of the coronavirus mouse hepatitis virus strain A59 (MHV-A59) is packaged into the virions, In this study, we show that a subgenomic (sg) defective interfering (DI) RNA can be packaged into virions when it contains the DI RNA packaging signal (DI RNA-Ps). However, the sg DI RNA is packaged less efficiently than the DI genomic INA, Thus, while specificity of packaging of RNAs into MHV-A59 visions is determined by the DI RNA-Ps, efficiency of packaging is determined by additional factors.

引用

页码：5684 / 5687

页数：4

共 20 条

[1] The production of recombinant infectious DI-particles of a murine coronavirus in the absence of helper virus [J].