Poor sensitivity of field rapid HIV testing: implications for mother-to-child transmission programme

被引：24

作者：

Black, V. ^{[1
]}

von Mollendorf, C. E. ^{[1
]}

Moyes, J. A. ^{[1
]}

Scott, L. E. ^{[2
,3
,4
]}

Puren, A. ^{[5
]}

Stevens, W. S. ^{[2
,3
,4
]}

机构：

[1] Univ Witwatersrand, Reprod Hlth & HIV Res Unit, Johannesburg, South Africa

[2] Univ Witwatersrand, Sch Pathol, Fac Hlth Sci, Dept Mol Med & Haematol, Johannesburg, South Africa

[3] Univ S Africa, Witwatersrand Med Sch, Johannesburg, South Africa

[4] Natl Hlth Lab Serv, Johannesburg, South Africa

[5] Natl Inst Communicable Dis, Specialized Mol Diagnost Unit, Johannesburg, South Africa

来源：

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2009年 / 116卷 / 13期

关键词：

HIV; PMTCT; Rapid HIV test;

D O I：

10.1111/j.1471-0528.2009.02357.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

We validated rapid HIV tests among pregnant women in a clinical setting. Field testing was performed using First Response 1,2,3 or Standard Diagnostic and Pareekshak tests. Results were confirmed by third generation HIV ELISA. Discordant or negative, specimens were confirmed by RNA PCR and a fourth generation ELISA test. Sensitivity and specificity were 94.5% (CI: 85.8-98.2) and 100% for First Response; 87.5% (CI: 46.7-99.3) and 100% (CI: 87.7-100%) for Standard Diagnostic and 90.2% (CI: 81.2-95.4) and 100% (CI: 98-100%) for Pareekshak. These sensitivities were lower than laboratory validation which approached 100%. The low-field sensitivity results have implications for Prevention of Mother-to-Child Transmission services.

引用

页码：1805 / 1808

页数：4