Photochromic Blockers of Voltage-Gated Potassium Channels

被引：176

作者：

Banghart, Matthew R. ^{[3
]}

Mourot, Alexandre ^{[1
]}

Fortin, Doris L. ^{[1
]}

Yao, Jennifer Z. ^{[3
]}

Kramer, Richard H. ^{[1
]}

Trauner, Dirk ^{[2
,3
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cellular Biol, Berkeley, CA 94720 USA

[2] Univ Munich, Dept Chem, D-81377 Munich, Germany

[3] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 48期

基金：

美国国家卫生研究院;

关键词：

azo compounds; ion channels; open-channel block; photochromism; structure-activity relationships; ANOMALOUS RECTIFICATION; ACETYLCHOLINE-RECEPTOR; TEA BLOCKADE; ION CHANNELS; K+-CHANNELS; GIANT AXONS; INACTIVATION; CONDUCTANCE; ANTAGONIST; SITE;

D O I：

10.1002/anie.200904504

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Light work: Studies into the mechanism of AAQ, a photoswitchable blocker of voltage-gated K+ channels, led to the discovery and development of photochromic ligands that act at the internal tetraethylammonium binding site (see picture). These molecules can be applied from the extracellular side to impart longlasting photosensitivity on K+ channels in living cells and thereby afford photocontrol of action potential firing in neurons. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9097 / 9101

页数：5

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