Print-and-Peel Fabricated Passive Micromixers

被引:23
作者
Thomas, Marlon S. [1 ]
Clift, Joseph M. [1 ]
Millare, Brent [1 ]
Vullev, Valentine I. [1 ]
机构
[1] Univ Calif Riverside, Dept Bioengn, Riverside, CA 92521 USA
关键词
SHRINKY-DINK MICROFLUIDICS; PROTEIN SEPARATION; FLOW; DEVICES; DESIGN; MIXER; TECHNOLOGY; GENERATION; ADHESION; PHYSICS;
D O I
10.1021/la902886d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Advection driven mixing is essential for microfluidics and poses challenges to the design of microdevices. Force transducers or complex channel configurations provide means for, respectively, active or passive disrupting of laminar flows and for homogenizing the composing fluids. Print-and-peel (PAP) is a nonlithographic fabrication technique that involves direct printing of masters for molding polymer components of microdevices. PAP, hence, allows for facile and expedient preparation of microfluidic devices, Without requiring access to specialized microfabrication facilities. We utilized PAP for fabrication of microfluidic devices capable of turning, expanding, and contracting microflows. We examined the mixing capabilities of these devices under flow conditions of small Reynolds numbers (0.2-20) and large Peclet numbers (260-26 000), under which advection is the dominant mode or mass transfer. We focused oil mixing channels with arched shapes and examined the dependence of the mixing performance oil the turns and the expansions along the direction of the microflows. Three-dimensional expansion and contraction, along with an increase in the modes of twisting of the laminar currents, improved the quality of mixing. The simplicity in the described fabrication of the investigated passive micromixers makes PAP ail attractive alternative for expedient device prototyping.
引用
收藏
页码:2951 / 2957
页数:7
相关论文
共 55 条
[1]   The Digital Revolution: A New Paradigm for Microfluidics [J].
Abdelgawad, Mohamed ;
Wheeler, Aaron R. .
ADVANCED MATERIALS, 2009, 21 (08) :920-925
[2]   Electrochemical energy generation and storage.: Fuel cells and lithium-ion batteries [J].
Abruña, Hector D. ;
Matsumoto, Futoshi ;
Cohen, Jamie L. ;
Jin, Jing ;
Roychowdhury, Chandrani ;
Prochaska, Mark ;
van Dover, R. Bruce ;
DiSalvo, Frank J. ;
Kiya, Yasuyuki ;
Henderson, Jay C. ;
Hutchison, Geoffrey R. .
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2007, 80 (10) :1843-1855
[3]   Bioinspired Design of a Hierarchically Structured Adhesive [J].
Arul, Edward Peter ;
Ghatak, Animangsu .
LANGMUIR, 2009, 25 (01) :611-617
[4]   Controlled microfluidic interfaces [J].
Atencia, J ;
Beebe, DJ .
NATURE, 2005, 437 (7059) :648-655
[5]   Physics and applications of microfluidics in biology [J].
Beebe, DJ ;
Mensing, GA ;
Walker, GM .
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2002, 4 :261-286
[6]   FLOW IN CURVED PIPES [J].
BERGER, SA ;
TALBOT, L ;
YAO, LS .
ANNUAL REVIEW OF FLUID MECHANICS, 1983, 15 :461-512
[7]   Biotechnology at low Reynolds numbers [J].
Brody, JP ;
Yager, P ;
Goldstein, RE ;
Austin, RH .
BIOPHYSICAL JOURNAL, 1996, 71 (06) :3430-3441
[8]   Microfluidic mixers: from microfabricated to self-assembling devices [J].
Campbell, CJ ;
Grzybowski, BA .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 2004, 362 (1818) :1069-1086
[9]   Shrinky-Dink microfluidics: 3D polystyrene chips [J].
Chen, Chi-Shuo ;
Breslauer, David N. ;
Luna, Jesus I. ;
Grimes, Anthony ;
Chin, Wei-Chun ;
Leeb, Luke P. ;
Khine, Michelle .
LAB ON A CHIP, 2008, 8 (04) :622-624
[10]   Two-dimensional protein separation in microfluidic devices [J].
Chen, Hong ;
Fan, Z. Hugh .
ELECTROPHORESIS, 2009, 30 (05) :758-765