Renal-cell carcinoma - Molecular pathways and therapies

被引:208
作者
Brugarolas, James [1 ]
机构
[1] Univ Texas, SW Med Sch, Div Hematol Oncol, Dallas, TX 75235 USA
[2] Univ Texas, SW Med Ctr, Simmons Comprehens Canc Ctr, Dallas, TX USA
关键词
D O I
10.1056/NEJMe068263
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:185 / 187
页数:3
相关论文
共 12 条
  • [1] TSC2 regulates VEGF through mTOR-dependent and -independent pathways
    Brugarolas, JB
    Vazquez, F
    Reddy, A
    Sellers, WR
    Kaelin, WG
    [J]. CANCER CELL, 2003, 4 (02) : 147 - 158
  • [2] Sorafenib in advanced clear-cell renal-cell carcinoma
    Escudier, Bernard
    Eisen, Tim
    Stadler, Walter M.
    Szczylik, Cezary
    Oudard, Stephane
    Siebels, Michael
    Negrier, Sylvie
    Chevreau, Christine
    Solska, Ewa
    Desai, Apurva A.
    Rolland, Frederic
    Demkow, Tomasz
    Hutson, Thomas E.
    Gore, Martin
    Freeman, Scott
    Schwartz, Brian
    Shan, Minghua
    Simantov, Ronit
    Bukowski, Ronald M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (02) : 125 - 134
  • [3] A small molecule-kinase interaction map for clinical kinase inhibitors
    Fabian, MA
    Biggs, WH
    Treiber, DK
    Atteridge, CE
    Azimioara, MD
    Benedetti, MG
    Carter, TA
    Ciceri, P
    Edeen, PT
    Floyd, M
    Ford, JM
    Galvin, M
    Gerlach, JL
    Grotzfeld, RM
    Herrgard, S
    Insko, DE
    Insko, MA
    Lai, AG
    Lélias, JM
    Mehta, SA
    Milanov, ZV
    Velasco, AM
    Wodicka, LM
    Patel, HK
    Zarrinkar, PP
    Lockhart, DJ
    [J]. NATURE BIOTECHNOLOGY, 2005, 23 (03) : 329 - 336
  • [4] RESULTS OF TREATMENT OF 255 PATIENTS WITH METASTATIC RENAL-CELL CARCINOMA WHO RECEIVED HIGH-DOSE RECOMBINANT INTERLEUKIN-2 THERAPY
    FYFE, G
    FISHER, RI
    ROSENBERG, SA
    SZNOL, M
    PARKINSON, DR
    LOUIE, AC
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1995, 13 (03) : 688 - 696
  • [5] Hudes G, 2006, J CLIN ONCOL, V24, p930S
  • [6] Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin
    Hudson, CC
    Liu, M
    Chiang, GG
    Otterness, DM
    Loomis, DC
    Kaper, F
    Giaccia, AJ
    Abraham, RT
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (20) : 7004 - 7014
  • [7] The von Hippel-Lindau tumor suppressor gene and kidney cancer
    Kaelin, WG
    [J]. CLINICAL CANCER RESEARCH, 2004, 10 (18) : 6290S - 6295S
  • [8] Inhibition of HIF2α is sufficient to suppress pVHL-defective tumor growth
    Kondo, K
    Kim, WY
    Lechpammer, M
    Kaelin, WG
    [J]. PLOS BIOLOGY, 2003, 1 (03): : 439 - 444
  • [9] mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
    Majumder, PK
    Febbo, PG
    Bikoff, R
    Berger, R
    Xue, Q
    McMahon, LM
    Manola, J
    Brugarolas, J
    McDonnell, TJ
    Golub, TR
    Loda, M
    Lane, HA
    Sellers, WR
    [J]. NATURE MEDICINE, 2004, 10 (06) : 594 - 601
  • [10] Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    Motzer, Robert J.
    Hutson, Thomas E.
    Tomczak, Piotr
    Michaelson, M. Dror
    Bukowski, Ronald M.
    Rixe, Olivier
    Oudard, Stephane
    Negrier, Sylvie
    Szczylik, Cezary
    Kim, Sindy T.
    Chen, Isan
    Bycott, Paul W.
    Baum, Charles M.
    Figlin, Robert A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (02) : 115 - 124