Polymorphism of egfr Intron1 is associated with susceptibility and severity of asthma

被引：15

作者：

Wang, Xintao ^{[1
]}

Saito, Junpei ^{[1
]}

Ishida, Takashi ^{[1
]}

Munakata, Mitsuru ^{[1
]}

机构：

[1] Fukushima Med Univ, Sch Med, Dept Pulm Med, Fukushima 9601295, Japan

来源：

JOURNAL OF ASTHMA | 2006年 / 43卷 / 09期

关键词：

asthma; case-control study; epidermal growth factor receptor; polymorphism; severity;

D O I：

10.1080/02770900600925247

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

To clarify the associations of the egfr CA repeat polymorphism with asthma and its severity, we examined 579 Japanese asthmatics and 232 control subjects. The number of CA repeat ranges from 9 to 24. Asthmatic patients had a significantly higher incidence of having shorter alleles (<= 16 CA repeats) compared with control subjects (p < 0.05). The most severe asthmatic patients have the highest frequency of short alleles (p < 0.05). In addition, subjects treated with leukotriene modifiers had higher incidence of having shorter allele compared to those without it (p < 0.01). Thus, the egfr CA repeat polymorphism is associated with the susceptibility and the severity of asthma.

引用

页码：711 / 715

页数：5

共 33 条

[1] MARKED GOBLET CELL HYPERPLASIA WITH MUCUS ACCUMULATION IN THE AIRWAYS OF PATIENTS WHO DIED OF SEVERE ACUTE ASTHMA ATTACK [J].

AIKAWA, T ;

SHIMURA, S ;

SASAKI, H ;

EBINA, M ;

TAKISHIMA, T .

CHEST, 1992, 101 (04) :916-921

[2] An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors [J].

Amador, ML ;

Oppenheimer, D ;

Perea, S ;

Maitra, A ;

Cusati, G ;

Iacobuzio-Donahue, C ;

Baker, SD ;

Ashfaq, R ;

Takimoto, C ;

Forastiere, A ;

Hidalgo, M .

CANCER RESEARCH, 2004, 64 (24) :9139-9143

[3] Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway [J].

Amishima, M ;

Munakata, M ;

Nasuhara, Y ;

Sato, A ;

Takahashi, T ;

Homma, Y ;

Kawakami, Y .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 157 (06) :1907-1912

[4]

[Anonymous], 2002, GLOBAL INITIATIVE AS

[5] ASTHMA - A DISEASE REMODELING THE AIRWAYS [J].

BOUSQUET, J ;

CHANEZ, P ;

LACOSTE, JY ;

WHITE, R ;

VIC, P ;

GODARD, P ;

MICHEL, FB .

ALLERGY, 1992, 47 (01) :3-11

[6] Asthma - From bronchoconstriction to airways inflammation and remodeling [J].

Bousquet, J ;

Jeffery, PK ;

Busse, WW ;

Johnson, M ;

Vignola, AM .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (05) :1720-1745

[7] Modification of breast cancer risk in young women by a polymorphic sequence in the egfr gene [J].

Brandt, B ;

Hermann, S ;

Straif, K ;

Tidow, N ;

Buerger, H ;

Chang-Claude, J .

CANCER RESEARCH, 2004, 64 (01) :7-12

[8]

Buerger H, 2000, CANCER RES, V60, P854

[9]

CARPENTER G, 1990, J BIOL CHEM, V265, P7709

[10]

Davies DE, 1999, ALLERGY, V54, P771

← 1 2 3 4 →