Base excision repair of DNA in mammalian cells

被引：300

作者：

Krokan, HE ^{[1
]}

Nilsen, H ^{[1
]}

Skorpen, F ^{[1
]}

Otterlei, M ^{[1
]}

Slupphaug, G ^{[1
]}

机构：

[1] Norwegian Univ Sci & Technol, Inst Canc Res & Mol Biol, N-7489 Trondheim, Norway

来源：

FEBS LETTERS | 2000年 / 476卷 / 1-2期

关键词：

DNA damage; base excision repair; DNA glycosylase;

D O I：

10.1016/S0014-5793(00)01674-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Base excision repair (BFR) of DNA corrects a number of spontaneous and environmentally induced genotoxic or miscoding base lesions in a process initiated by DNA glycosylases. An AP endonuclease cleaves at the 5' side of the abasic site and the repair process is subsequently completed via either short patch repair or long patch repair, which largely require different proteins. As one example, the UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) uracil DNA glycosylase and prevents accumulation of uracil in the genome. BER is likely to have a major role in preserving the integrity of DNA during evolution and may prevent cancer. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B,V. All rights reserved.

引用

页码：73 / 77

页数：5

共 36 条

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