Serum level of soluble tumour necrosis factor receptor II (75 kDa) indicates inflammatory activity of sarcoidosis

被引:26
作者
Ziegenhagen, MW
Fitschen, J
Martinet, N
Schlaak, M
Müller-Quernheim, J
机构
[1] Hosp Med, Res Ctr Borstel, D-23845 Borstel, Germany
[2] INSERM, U14, F-54511 Vandoeuvre Les Nancy, France
关键词
disease activity; sarcoidosis; soluble TNF receptor;
D O I
10.1046/j.1365-2796.2000.00685.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives. Tumour necrosis factor alpha (TNF alpha) is a key cytokine involved in granuloma formation of sarcoidosis. Since soluble TNF receptors (sTNF-R) are known to inhibit TNF effects, we were interested in whether they are elevated in the serum of sarcoidosis patients. Methods. We determined serum levels of sTNF-R I (55 kDa) and sTNF-R II (75 kDa) in 49 patients with sarcoidosis and 22 controls. The clinical course of the disease was re-evaluated in a follow-up after (mean +/- SE) 6.8 +/- 6.6 months. Results. sTNF-R I (3.1 +/- 1.1 ng mL(-1), P < 0.05) and sTNF-R II (5.5 +/- 2.7 ng mL(-1), P < 0.0005) were significantly elevated in sarcoidosis compared with controls (2.4 +/- 0.7 and 3.0 +/- 1.3 ng mL(-1), respectively). Interestingly, both sTNF receptors were significantly higher in the serum of patients with active compared with inactive sarcoidosis (P < 0.005 and P < 0.0005, respectively). Furthermore, serum sTNF-R II levels were significantly higher in sarcoidosis patients with advanced radiological types II and III. In 10 patients, serum sTNF-R levels were obtained before and after systemic corticosteroid therapy and we observed a significant decrease of sTNF-R II (P < 0.02), whereas sTNF-R I levels were not reduced significantly. Conclusions. Both types of sTNF receptors are elevated in the serum of sarcoidosis patients with active disease, but only the sTNF-R II seems to be useful for monitoring the inflammatory activity of the disease.
引用
收藏
页码:33 / 41
页数:9
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