Maintained improvement with minocycline of a patient with advanced Huntington's disease

被引：23

作者：

Denovan-Wright, EM

Devarajan, S

Dursun, SM

Robertson, HA ^{[1
]}

机构：

[1] Dalhousie Univ, Fac Med, Dept Pharmacol, Halifax, NS B3H 4H7, Canada

[2] Dalhousie Univ, Fac Med, Dept Psychiat, Halifax, NS B3H 4H7, Canada

来源：

JOURNAL OF PSYCHOPHARMACOLOGY | 2002年 / 16卷 / 04期

关键词：

antiapoptotic agent; antibiotic; basal ganglia; neurodegeneration; tetracycline;

D O I：

10.1177/026988110201600417

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present the ease of a patient with advanced Huntington's disease treated with minocycline. Minocycline (but not tetracycline which does not cross the blood-brain barrier) appears to increase longevity in an animal model for Huntington's disease. The patient has been maintained on minocycline for more than 1 year with positive effects. Cessation of minocyclin for 3 weeks resulted in an exacerbation of symptoms. The animal studies have suggested that minocycline may prevent progression of Huntington's disease and other neurological disorders. By contrast, this present result suggests that minocycline may benefit those with advanced Huntington's disease and can be used safely in these patients.

引用

页码：393 / 394

页数：2

共 3 条

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