A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans

被引：51

作者：

Thiel, BA

Chakravarti, A

Cooper, RS

Luke, A

Lewis, S

Lynn, A

Tiwari, H

Schork, NJ

Weder, AB

机构：

[1] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

[2] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD USA

[3] Loyola Univ, Stritch Sch Med, Dept Prevent Med & Epidemiol, Maywood, IL 60153 USA

[4] Univ Michigan, Sch Med, Dept Med, Ann Arbor, MI 48104 USA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 2003年 / 16卷 / 02期

关键词：

hypertension; blood pressure; genetics; heredity; linkage analysis;

D O I：

10.1016/S0895-7061(02)03246-6

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Evidence for genomic regions influencing systolic and diastolic blood pressure (BP) were assessed in a whole genome linkage analysis in 211 African American and 160 white families as part of the GenNet network of the National Heart, Lung and Blood Institute-sponsored Family Blood Pressure Program. Multipoint regression and variance components linkage methods were used to analyze 372 polymorphic markers. Statistically compelling evidence for linkage (P values .0057 and .00023, respectively) was found on chromosome 1. Our results support the idea that BP regulation is most likely governed by multiple genetic loci, each with a relatively weak effect on BP in the population at large. (C) 2003 American Journal of Hypertension, Ltd.

引用

页码：151 / 153

页数：3

共 15 条

[1]

Boerwinkle E, 2002, HYPERTENSION, V39, P3

[2]

Kruglyak L, 1996, AM J HUM GENET, V58, P1347

[3] GENETIC DISSECTION OF COMPLEX TRAITS - GUIDELINES FOR INTERPRETING AND REPORTING LINKAGE RESULTS [J].