A patch clamp study of a glutamatergic chloride channel on pharyngeal muscle of the nematode Ascaris suum

被引：17

作者：

Adelsberger, H

Scheuer, T

Dudel, J

机构：

[1] Physiologisches Institut, Tech. Universität München, D-80802 München

来源：

NEUROSCIENCE LETTERS | 1997年 / 230卷 / 03期

关键词：

glutamate; ivermectin; parasite; single channel; outside-out patch;

D O I：

10.1016/S0304-3940(97)00512-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glutamatergic chloride channels on the pharyngeal muscle of Ascaris suum could be activated with glutamate and ivermectin and reversibly blocked with picrotoxin using the patch clamp technique. No activation was observed with GABA, glycine and acetylcholine. Most of the current was carried by the main subconductance state of 21 pS. Two smaller subconductance states occurred rarely. Open time histograms could be best fitted by two time constants of tau(o1) = 0.33 ms and tau(o2) = 9.8 ms present at all glutamate concentrations applied. The results suggest that some properties of the channel investigated here are different from other glutamatergic chloride channels reported from various animals. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：183 / 186

页数：4

共 17 条

[1] A molecular scheme for the reaction between gamma-aminobutyric acid and the most abundant chloride channel on crayfish deep extensor abdominal muscle [J].