Tec family kinases in lymphocyte signaling and function

被引：87

作者：

Schaeffer, EM

Schwartzberg, PL

机构：

[1] Natl Human Genome Res Inst, NIH, Bethesda, MD 20892 USA

[2] Univ Chicago, Dept Pathol, Biomed Sci Cluster, Chicago, IL 60637 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(00)00088-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Tec kinases are required for full Ca2+ mobilization in lymphocytes. Recent data suggest that this process occurs via a multiprotein complex that includes LAT and SLP-76 in T cells and BLNK/SLP-65 in B cells. Mutational analyses have revealed critical roles for Tec kinases in lymphocyte development and function.

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页码：282 / 288

页数：7

相关论文

共 66 条

[1] Regulatory intramolecular association in a tyrosine kinase of the Tec family [J].

Andreotti, AH ;

Bunnell, SC ;

Feng, S ;

Berg, LJ ;

Schreiber, SL .

NATURE, 1997, 385 (6611) :93-97

[2] Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase [J].

August, A ;

Sadra, A ;

Dupont, B ;

Hanafusa, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (21) :11227-11232

[3] SHIP modulates immune receptor responses by regulating membrane association of Btk [J].

Bolland, S ;

Pearse, RN ;

Kurosaki, T ;

Ravetch, JV .

IMMUNITY, 1998, 8 (04) :509-516

[4] Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade [J].

Bunnell, SC ;

Diehn, M ;

Yaffe, MB ;

Findell, PR ;

Cantley, LC ;

Berg, LJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (03) :2219-2230

[5] Signal transduction from the B cell antigen-receptor [J].

Campbell, KS .

CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (03) :256-264

[6]

Ching KA, 1999, J IMMUNOL, V163, P6006

[7]

Choi YB, 1999, J IMMUNOL, V163, P5242

[8] Drosophila ring canal growth requires Src and Tec kinases [J].

Cooley, L .

CELL, 1998, 93 (06) :913-915

[9]

Debnath J, 1999, MOL CELL BIOL, V19, P1498

[10] Differential activation of transcription factors induced by Ca2+ response amplitude and duration (vol 386, pg 855, 1997) [J].

Dolmetsch, RE ;

Lewis, RS ;

Goodnow, CC ;

Healy, JI .

NATURE, 1997, 388 (6639) :308-308

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